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ME2082d Malignant melanoma with skin tissue array, including TNM and clinical stage, 204 cases/208 cores, replacing ME2082c
Product Image
Cores 192 Cases 188
Row number 12 Column number 16
Core Diameter(mm) 1.0 Thickness(µm) 5.0
Tissue Array Type FFPE Species Human
QA/QC H&E, IHC S-100 and HMB45
Applications 常规组织学操作包括免疫组织化学(IHC)和原位杂交(ISH),可以在我们的技术支持页面找到操作流程。
Notes 1. 收到产品后请在4°保存,并在3个月内使用;
2. 请在实验前60°烤片30分钟;
3.请选择温和的修复方式,以免造成组织脱落。

ME2082d

Malignant melanoma with skin tissue microarray, containing 112 cases malignant melanoma, 64 metastatic malignant melanoma (4 cases matched with malignant melanoma), 8 adjacent normal skin tissue, 8 skin tissue, single core per block

分类: Human Paraffin Embedded Tissue Array   Melanoma  

亚分类: Multiple organs   Metastasis   Stage (TNM)  

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Alenabio
ME2082d(serial)
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
A
Ski
Par
Eso
Eso
Sma
Sma
Rec
Rec
Rec
Rec
Rec
Rec
Rec
Rec
Rec
Rec
B
Rec
Rec
Rec
Rec
Rec
Ski
Ski
Sto
Sto
Vul
Vul
Vul
Vul
Vul
Vul
Vul
C
Cer
Ski
Med
Ski
Cer
Ure
Scr
Scr
Scr
Ski
Nos
Nos
Max
Nos
Nos
Ski
D
Ski
Ski
Rec
Ski
Ski
Ski
Ski
Ski
Ski
Ski
Ski
Ski
Ski
Ski
Ski
Ski
E
Ski
Ski
Ski
Ski
Ski
Ski
Ski
Ski
Ski
Ski
Ski
Ski
Ski
Ski
Ski
Ski
F
Ski
Ski
Ski
Ski
Ski
Ski
Ski
Ski
Ski
Ski
Ski
Ski
Ski
Ski
Ski
Ski
G
Ski
Ski
Ski
Ski
Eye
Eye
Eye
Eye
Eye
Eye
Eye
Eye
Eye
Eye
Eye
Eye
H
Lym
Lym
Lym
Lym
Lym
Lym
Lym
Lym
Lym
Lym
Lym
Lym
Lym
Lym
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Lym
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Lym
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Lym
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L
Ski
Ski
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Ski
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Adr
ME2082d  (-)
Age:
Sex:
Organ/Anatomic Site:
Pathology diagnosis:
TNM:
Grade:
Stage:
Type:

Legend: Cer-Cerebrum Cer-Cervix Eso-Esophagus Eye-Eye Lym-Lymph node Max-Maxillary sinus Med-Mediastinum Nos-Nose Par-Parotid gland Rec-Rectum Scr-Scrotum Ski-Skin Sma-Small intestine Sto-Stomach Ure-Urethra Vul-Vulva

  • Malignant
  • Malignant(IA)
  • Malignant(IB)
  • Malignant(IIA)
  • Malignant(IIB)
  • Malignant(IIC)
  • Malignant(III)
  • Malignant(IV)
  • Metastasis
  • NAT
  • Normal
Pos. No. Age Sex Organ/Anatomic Site Pathology diagnosis TNM Grade stage Type
A1 1 40 M Skin Malignant melanoma of right chest wall T4aN0M0 IIB Malignant
A2 2 70 F Parotid gland Malignant melanoma of left parotid gland - - Malignant
A3 3 50 M Esophagus Malignant melanoma - - Malignant
A4 4 64 M Esophagus Malignant melanoma - - Malignant
A5 5 73 M Small intestine Malignant melanoma - - Malignant
A6 6 71 M Small intestine Malignant melanoma - - Malignant
A7 7 64 M Rectum Malignant melanoma - - Malignant
A8 8 42 F Rectum Malignant melanoma - - Malignant
A9 9 67 M Rectum Malignant melanoma - - Malignant
A10 10 67 F Rectum Malignant melanoma - - Malignant
A11 11 66 F Rectum Malignant melanoma (sparse) - - Malignant
A12 12 47 M Rectum Malignant melanoma - - Malignant
A13 13 64 F Rectum Malignant melanoma - - Malignant
A14 14 75 M Rectum Malignant melanoma - - Malignant
A15 15 66 M Rectum Malignant melanoma - - Malignant
A16 16 54 F Rectum Malignant melanoma - - Malignant
B1 17 52 F Rectum Malignant melanoma - - Malignant
B2 18 82 F Rectum Malignant melanoma of anal canal T4aN0M0 IIB Malignant
B3 19 57 M Rectum Malignant melanoma of anal canal T4aN0M0 IIB Malignant
B4 20 84 F Rectum Malignant melanoma of anus T4bN0M0 IIC Malignant
B5 21 69 F Rectum Malignant melanoma of anal canal (sparse) T4bN3M1 IV Malignant
B6 22 62 F Skin Malignant melanoma of left sole of foot T4aN0M0 IIB Malignant
B7 23 31 M Skin Malignant melanoma of left upper arm T4N1M0 III Malignant
B8 24 55 M Stomach Malignant melanoma - - Malignant
B9 25 55 M Stomach Malignant melanoma - - Malignant
B10 26 41 F Vulva Malignant melanoma T4aN0M0 IIB Malignant
B11 27 34 F Vulva Malignant melanoma T4aN0M0 IIB Malignant
B12 28 45 F Vulva Malignant melanoma T4aN0M0 IIB Malignant
B13 29 38 F Vulva Malignant melanoma T4aN0M0 IIB Malignant
B14 30 62 F Vulva Malignant melanoma of vagina - - Malignant
B15 31 44 F Vulva Malignant melanoma T4aN0M0 IIB Malignant
B16 32 57 F Vulva Malignant melanoma T4aN0M0 IIB Malignant
C1 33 44 F Cervix Malignant melanoma - - Malignant
C2 34 62 F Skin Malignant melanoma of right foot T4aN0M0 IIB Malignant
C3 35 51 M Mediastinum Malignant melanoma - - Malignant
C4 36 72 F Skin Malignant melanoma of waist T4aN0M0 IIB Malignant
C5 37 50 F Cerebrum Malignant melanoma of left cerebrum T4aN0M0 IIB Malignant
C6 38 62 F Urethra Malignant melanoma - - Malignant
C7 39 62 M Scrotum Malignant melanoma T4bN0M0 IIC Malignant
C8 40 46 M Scrotum Malignant melanoma T4aN0M0 IIB Malignant
C9 41 55 M Scrotum Malignant melanoma T4N1M0 III Malignant
C10 42 64 M Skin Malignant melanoma of sole of foot T4aN0M0 IIB Malignant
C11 43 78 M Nose Malignant melanoma of left nasal cavity - - Malignant
C12 44 38 F Nose Malignant melanoma of left nasal cavity - - Malignant
C13 45 56 F Maxillary sinus Malignant melanoma of right maxillary sinus - - Malignant
C14 46 50 M Nose Malignant melanoma - - Malignant
C15 47 63 M Nose Malignant melanoma - - Malignant
C16 48 71 F Skin Malignant melanoma of right sole of foot T2aN0M0 IB Malignant
D1 49 49 F Skin Malignant melanoma with necrosis of back T4aN0M0 IIB Malignant
D2 50 45 F Skin Malignant melanoma of left thigh T4aN0M0 IIB Malignant
D3 51 38 F Rectum Malignant melanoma - - Malignant
D4 52 49 M Skin Malignant melanoma of left thigh T4aN0M0 IIB Malignant
D5 53 65 M Skin Malignant melanoma of right sole of foot T2bN0M0 IB Malignant
D6 54 42 F Skin Malignant melanoma of right thigh T4aN0M0 IIB Malignant
D7 55 71 M Skin Malignant melanoma of right buttock T4aN0M0 IIB Malignant
D8 56 67 F Skin Malignant melanoma of right armpit T2aN0M0 IB Malignant
D9 57 42 F Skin Malignant melanoma of left thumb T4bN0M0 IIC Malignant
D10 58 58 F Skin Malignant melanoma of left buttock T4aN0M0 IIB Malignant
D11 59 50 M Skin Malignant melanoma of left shoulder T4aN0M0 IIB Malignant
D12 60 7 M Skin Malignant melanoma of sacrococcygeal region T4aN0M0 IIB Malignant
D13 61 25 M Skin Malignant melanoma of left sole of foot T4bN0M0 IIC Malignant
D14 62 66 M Skin Malignant melanoma of sole of foot T4bN0M0 IIC Malignant
D15 63 45 F Skin Malignant melanoma of chest wall T4aN0M0 IIB Malignant
D16 64 41 M Skin Malignant melanoma of left forearm T4aN0M0 IIB Malignant
E1 65 57 M Skin Malignant melanoma of left shoulder T4aN0M0 IIB Malignant
E2 66 52 M Skin Malignant melanoma of left lower abdominal wall T4bN0M0 IIC Malignant
E3 67 56 M Skin Malignant melanoma of abdominal wall T4aN0M0 IIB Malignant
E4 68 54 F Skin Malignant melanoma of left foot T4aN0M0 IIB Malignant
E5 69 83 F Skin Malignant melanoma of right little finger T4bN0M0 IIC Malignant
E6 70 46 F Skin Malignant melanoma of thigh T4bN0M0 IIC Malignant
E7 71 38 M Skin Malignant melanoma of right sole of foot T3N1M0 III Malignant
E8 72 49 M Skin Malignant melanoma of left buttock T4bN0M0 IIC Malignant
E9 73 65 M Skin Malignant melanoma of scalp T4aN0M0 IIB Malignant
E10 74 61 F Skin Malignant melanoma of left foot T4bN0M0 IIC Malignant
E11 75 32 F Skin Malignant melanoma of right waist (sparse) T4aN0M0 IIB Malignant
E12 76 41 M Skin Malignant melanoma of left leg T4aN0M0 IIB Malignant
E13 77 51 M Skin Malignant melanoma of back T4aN0M0 IIB Malignant
E14 78 42 M Skin Malignant melanoma of left heel T4N2M0 III Malignant
E15 79 63 F Skin Malignant melanoma of right heel T4bN0M0 IIC Malignant
E16 80 62 F Skin Malignant melanoma of right thumb T4aN0M0 IIB Malignant
F1 81 69 M Skin Malignant melanoma of sole of foot T2bN0M0 IB Malignant
F2 82 38 F Skin Malignant melanoma of left upper arm T4N1M0 III Malignant
F3 83 55 M Skin Malignant melanoma of sole of foot T4aN0M0 IIB Malignant
F4 84 51 M Skin Malignant melanoma of right upper arm T4N1M0 III Malignant
F5 85 74 F Skin Malignant melanoma of back T4aN0M0 IIB Malignant
F6 86 45 M Skin Malignant melanoma of crissum T4aN0M0 IIB Malignant
F7 87 60 M Skin Malignant melanoma of left sole of foot T4bN0M0 IIC Malignant
F8 88 71 M Skin Malignant melanoma of right groin T4aN0M0 IIB Malignant
F9 89 59 F Skin Malignant melanoma of right buttock (sparse) T1aN0M0 IA Malignant
F10 90 66 F Skin Malignant melanoma of chest wall T4aN0M0 IIB Malignant
F11 91 43 F Skin Malignant melanoma of left leg T4bN0M0 IIC Malignant
F12 92 80 M Skin Malignant melanoma of right sole of foot T4aN0M0 IIB Malignant
F13 93 36 M Skin Malignant melanoma of right chest wall T4aN0M0 IIB Malignant
F14 94 31 M Skin Malignant melanoma of scalp T4aN0M0 IIB Malignant
F15 95 46 F Skin Malignant melanoma of right thumb T4aN0M0 IIB Malignant
F16 96 60 M Skin Malignant melanoma of right buttock T4aN1M0 III Malignant
G1 97 40 M Skin Malignant melanoma of right chest wall T4aN0M0 IIB Malignant
G2 98 37 M Skin Malignant melanoma of right upper arm T4aN0M0 IIB Malignant
G3 99 47 F Skin Malignant melanoma of right upper arm T4aN0M0 IIB Malignant
G4 100 43 F Skin Malignant melanoma of right upper abdominal wall T4aN0M0 IIB Malignant
G5 101 66 M Eye Malignant melanoma of right lower eyelid T4bN0M0 IIC Malignant
G6 102 52 M Eye Malignant melanoma o left eye T4aN0M0 IIB Malignant
G7 103 37 M Eye Malignant melanoma o left eye T3N1M0 III Malignant
G8 104 56 F Eye Malignant melanoma o right eye T3aN0M0 IIA Malignant
G9 105 45 F Eye Malignant melanoma o right eyeball T4aN0M0 IIB Malignant
G10 106 57 M Eye Malignant melanoma of right choroid T4aN0M0 IIB Malignant
G11 107 41 F Eye Malignant melanoma of right choroid T4aN0M0 IIB Malignant
G12 108 67 M Eye Malignant melanoma o right eye T2aN0M0 IB Malignant
G13 109 49 F Eye Malignant melanoma o right eyeball T4aN0M0 IIB Malignant
G14 110 35 F Eye Malignant melanoma of right choroid T4aN0M0 IIB Malignant
G15 111 62 F Eye Malignant melanoma of right choroid T4aN0M0 IIB Malignant
G16 112 57 M Eye Malignant melanoma of right choroid T4aN0M0 IIB Malignant
H1 113 65 M Lymph node Metastatic malignant melanoma of right groin - - Metastasis
H2 114 38 M Lymph node Metastatic malignant melanoma with necrosis of left armpit - - Metastasis
H3 115 49 M Lymph node Metastatic malignant melanoma of left armpit - - Metastasis
H4 116 49 F Lymph node Metastatic malignant melanoma with necrosis of neck - - Metastasis
H5 117 55 M Lymph node Metastatic malignant melanoma of left groin - - Metastasis
H6 118 40 F Lymph node Metastatic malignant melanoma of right groin - - Metastasis
H7 119 70 M Lymph node Metastatic malignant melanoma of armpit - - Metastasis
H8 120 68 F Lymph node Metastatic malignant melanoma of right groin from vulva - - Metastasis
H9 121 68 M Lymph node Metastatic malignant melanoma of neck - - Metastasis
H10 122 61 F Lymph node Metastatic malignant melanoma of right groin - - Metastasis
H11 123 65 M Lymph node Metastatic malignant melanoma of groin - - Metastasis
H12 124 46 M Lymph node Metastatic malignant melanoma of right groin - - Metastasis
H13 125 42 F Lymph node Metastatic malignant melanoma of groin - - Metastasis
H14 126 43 F Lymph node Metastatic malignant melanoma of groin - - Metastasis
H15 127 56 F Lymph node Metastatic malignant melanoma of right groin - - Metastasis
H16 128 56 F Lymph node Metastatic malignant melanoma of groin - - Metastasis
I1 129 63 F Lymph node Metastatic malignant melanoma of right groin - - Metastasis
I2 130 45 M Lymph node Metastatic malignant melanoma of right armpit - - Metastasis
I3 131 60 F Lymph node Metastatic malignant melanoma of neck - - Metastasis
I4 132 29 F Lymph node Metastatic malignant melanoma of neck - - Metastasis
I5 133 31 F Lymph node Metastatic malignant melanoma of neck - - Metastasis
I6 134 57 F Lymph node Metastatic malignant melanoma of right groin - - Metastasis
I7 135 60 F Lymph node Metastatic malignant melanoma of right groin - - Metastasis
I8 136 46 F Lymph node Metastatic malignant melanoma of right neck - - Metastasis
I9 137 49 M Lymph node Metastatic malignant melanoma of neck - - Metastasis
I10 138 58 F Lymph node Metastatic malignant melanoma of left groin - - Metastasis
I11 139 68 M Lymph node Metastatic malignant melanoma of right armpit - - Metastasis
I12 140 52 M Lymph node Metastatic malignant melanoma of left groin - - Metastasis
I13 141 53 F Lymph node Metastatic malignant melanoma of right groin - - Metastasis
I14 142 68 F Lymph node Metastatic malignant melanoma of left groin - - Metastasis
I15 143 38 F Lymph node Metastatic malignant melanoma of right groin - - Metastasis
I16 144 48 M Lymph node Metastatic malignant melanoma of groin - - Metastasis
J1 145 44 M Lymph node Metastatic malignant melanoma of right armpit - - Metastasis
J2 146 70 M Lymph node Metastatic malignant melanoma of groin - - Metastasis
J3 147 74 M Lymph node Metastatic malignant melanoma of left groin - - Metastasis
J4 148 47 F Lymph node Metastatic malignant melanoma of armpit - - Metastasis
J5 149 61 M Lymph node Metastatic malignant melanoma of right groin - - Metastasis
J6 150 38 M Lymph node Metastatic malignant melanoma of armpit - - Metastasis
J7 151 41 F Lymph node Metastatic malignant melanoma of groin - - Metastasis
J8 152 49 M Lymph node Metastatic malignant melanoma of left groin - - Metastasis
J9 153 45 F Lymph node Metastatic malignant melanoma of left chest wall of No.63 - - Metastasis
J10 154 58 M Lymph node Metastatic malignant melanoma of left groin - - Metastasis
J11 155 54 M Lymph node Metastatic malignant melanoma of left groin - - Metastasis
J12 156 45 F Lymph node Metastatic malignant melanoma of spleen - - Metastasis
J13 157 50 M Lymph node Metastatic malignant melanoma of paraesophageal lymph node of No.3 - - Metastasis
J14 158 50 M Lymph node Metastatic malignant melanoma of right parparotid lymph node - - Metastasis
J15 159 55 F Lymph node Metastatic malignant melanoma of right occipital lobe - - Metastasis
J16 160 62 M Lymph node Metastatic malignant melanoma of groin of No.39 - - Metastasis
K1 161 39 M Lymph node Metastatic malignant melanoma of left femur - - Metastasis
K2 162 56 M Lymph node Metastatic malignant melanoma of left preauricula - - Metastasis
K3 163 80 F Lymph node Metastatic malignant melanoma of right armpit - - Metastasis
K4 164 72 F Lymph node Metastatic malignant melanoma of left groin - - Metastasis
K5 165 62 M Lymph node Metastatic malignant melanoma of groin - - Metastasis
K6 166 41 F Lymph node Metastatic malignant melanoma of left groin - - Metastasis
K7 167 61 F Lymph node Metastatic malignant melanoma of right thigh - - Metastasis
K8 168 35 F Lymph node Metastatic malignant melanoma with necrosis of left armpit - - Metastasis
K9 169 41 F Lymph node Metastatic malignant melanoma of groin - - Metastasis
K10 170 72 M Lymph node Metastatic malignant melanoma of right groin - - Metastasis
K11 171 62 M Lymph node Metastatic malignant melanoma of left neck - - Metastasis
K12 172 48 M Lymph node Metastatic malignant melanoma of neck - - Metastasis
K13 173 49 M Lymph node Metastatic malignant melanoma of pelvic cavity - - Metastasis
K14 174 63 M Lymph node Metastatic malignant melanoma of right neck - - Metastasis
K15 175 71 M Lymph node Metastatic malignant melanoma of right armpit - - Metastasis
K16 176 67 F Lymph node Metastatic malignant melanoma of right armpit of No.56 - - Metastasis
L1 177 44 F Skin Adjacent normal skin tissue of breast - - NAT
L2 178 63 F Skin Adjacent normal skin tissue of breast - - NAT
L3 179 48 F Skin Adjacent normal skin tissue of breast - - NAT
L4 180 43 F Skin Adjacent normal skin tissue of breast - - NAT
L5 181 41 F Skin Adjacent normal skin tissue of breast - - NAT
L6 182 43 F Skin Adjacent normal skin tissue of breast - - NAT
L7 183 56 M Skin Adjacent normal skin tissue of breast - - NAT
L8 184 48 M Skin Adjacent normal skin tissue of crissum - - NAT
L9 185 19 F Skin Skin tissue of scalp - - Normal
L10 186 40 M Skin Skin tissue (sparse) - - Normal
L11 187 2 Mon. M Skin Skin tissue of scalp - - Normal
L12 188 40 M Skin Skin tissue - - Normal
L13 189 35 M Skin Skin tissue - - Normal
L14 190 47 M Skin Skin tissue - - Normal
L15 191 21 F Skin Skin tissue - - Normal
L16 192 21 M Skin Skin tissue - - Normal
- 42 M Adrenal gland Pheochromocytoma (tissue marker) - - - Malignant
Notes:“*” means invalid core; “-” means no classification or negative in IHC markers.

AJCC-TNM classification for mucosal melanoma of the head and neck

T3 Mucosal disease
Primary Tumour
T3Mucosal disease
T4a Moderately advanced disease. Tumour involving deep soft tissue, cartilage, one, or overlying skin.
T4bVery advanced disease. Tumour involving brain, dura, skull base, lower cranial nerves (IX, X, XI, XII), masticator space, carotid artery, prevertebral space or mediastinal structures
Regional lymph nodes
NXRegional lymph nodes cannot be assessed
N0No regional lymph node metastases
N1Regional lymph node metastases present

Clinical stage
Stage IIIT3N0M0
Stage IVAT4aN0M0
T3-T4aN1M0
Stage IVBT4bAny NM0
Stage IVCAny TAny NM1

Vulvovaginal mucosal melanoma
Vulval melanomas are staged using the same AJCC-TNM classification as the table above. There is no staging system for vaginal melanoma, so a simplified clinical staging system can be used to categorise these melanomas.
Vaginal melanoma
Stage IClinically localized disease
Stage IIRegional nodal involvement
Stage IIIDistant metastatic involvement

Anorectal mucosal melanoma
Anorectal mucosal melanoma is staged using the same simplified staging system as vaginal melanoma.
Anorectal mucosal melanoma
Stage IClinically localized disease
Stage IIRegional nodal involvement
Stage IIIDistant metastatic involvement
Melanoma of the skins
Primary tumor (T)
* TX: Primary tumor cannot be assessed (e.g., shave biopsy or regressed melanoma)
* T0: No evidence of primary tumor
* Tis: Melanoma in situ
* T1: Tumor 1.0 mm or less in thickness with or without ulceration
  * T1a: Tumor 1.0 mm or less in thickness and Clarks level II or III, no ulceration
  * T1b: Tumor 1.0 mm or less in thickness and Clarks level IV or V or with ulceration
* T2: Tumor more than 1.0 mm but not more than 2.0 mm in thickness with or without ulceration
  * T2a: Tumor more than 1.0 mm but not more than 2.0 mm in thickness, no ulceration
  * T2b: Tumor more than 1.0 mm but not more than 2.0 mm in thickness, with ulceration
* T3: Tumor more than 2.0 mm but not more than 4 mm in thickness with or without ulceration
  * T3a: Tumor more than 2.0 mm but not more than 4 mm in thickness, no ulceration
  * T3b: Tumor more than 2.0 mm but not more than 4 mm in thickness, with ulceration
* T4: Tumor more than 4.0 mm in thickness with or without ulceration
  * T4a: Tumor more than 4.0 mm in thickness, no ulceration
  * T4b: Tumor more than 4.0 mm in thickness, with ulceration


Regional lymph nodes (N)

* NX: Regional lymph nodes cannot be assessed
* N0: No regional lymph node metastasis
* N1: Metastasis to 1 lymph node
  * N1a: Clinically occult (microscopic) metastasis
  * N1b: Clinically apparent (macroscopic) metastasis
* N2: Metastasis to 2 or 3 regional nodes or intralymphatic regional metastasis without nodal metastases
  * N2a: Clinically occult (microscopic) metastasis
  * N2b: Clinically apparent (macroscopic) metastasis
  * N2c: Satellite or in transit metastasis without nodal metastasis
* N3: Metastasis in 4 or more regional nodes, or matted lymph nodes, or in transit metastasis or satellite(s) with metastatic regional node(s)
Note: Micrometastases are diagnosed after elective or sentinel lymphadenectomy; macrometastases are defined as clinically detectable lymph nodes metastases confirmed by therapeutic lymphadenectomy, or when any lymph node metastasis exhibits gross extracapsular extension.
Distant Metastasis (M)
* MX: Distant metastasis cannot be assessed
* M0: No distant metastasis
* M1: Distant metastasis
  * M1a: Metastasis to skin, subcutaneous tissues, or distant lymph nodes
  * M1b: Metastasis to lung
  * M1c: Metastasis to all other visceral sites or distant metastasis at any site associated with an elevated serum lactic dehydrogenase (LDH)

Stage Groupings
Stage 0
  Tis, N0, M0
Stage IA
   T1a, N0, M0
Stage IB
   T1b, N0, M0
   T2a, N0, M0
Stage IIA
  T2b, N0, M0
  T3a, N0, M0
Stage IIB
  T3b, N0, M0
  T4a, N0, M0
Stage IIC
  T4b, N0, M0
Stage III
  Any T, N1, M0
   Any T, N2, M0
  Any T, N3, M0
Stage IV
  Any T, any N, M1