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ME241b Multiple malignant melanoma tissue array with adjacent normal skin tissue, including TNM and clinical stage, 12 cases/24 cores, replacing ME241a
Product Image
Cores 24 Cases 12
Row number 4 Column number 6
Core Diameter(mm) 1.5 Thickness(µm) 5.0
Tissue Array Type FFPE Species Human
QA/QC 经H&E染色和免疫组化(IHC)染色验证
Applications 常规组织学操作包括免疫组织化学(IHC)和原位杂交(ISH),可以在我们的技术支持页面找到操作流程。
Notes 1. 收到产品后请在4°保存,并在3个月内使用;
2. 请在实验前60°烤片30分钟;
3.请选择温和的修复方式,以免造成组织脱落。

ME241b

Multiple malignant melanoma tissue microarray with adjacent normal skin tissue, containing 10 cases of malignant melanoma, plus 2 adjacent normal skin tissue, duplicate cores per case

分类: Human Paraffin Embedded Tissue Array   Melanoma  

亚分类: Duplicate cores per case   Multiple organs   With adjacent normal   Stage (TNM)  

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Alenabio
ME241b(serial)
1
2
3
4
5
6
A
Eso
Eso
Ski
Ski
Pa
Pa
B
Rec
Rec
Rec
Rec
Anu
Anu
C
Rec
Rec
Rec
Rec
Rec
Rec
D
Rec
Rec
Ski
Ski
Ski
Ski
Adr
ME241b  (-)
Age:-
Sex:
Organ(Anatomic Site):
Pathology diagnosis:
TNM:
Grade:
Stage:
Type:

Legend: Pa- Parotid gland Anu-Anus Eso-Esophagus Rec-Rectum Ski-Skin

  • Malignant
  • Malignant(II)
  • NAT
Pos. No. Age Sex Organ Pathology diagnosis TNM Grade stage Type
A1 1 50 M Esophagus Malignant melanoma of esophagus - - Malignant
A2 2 50 M Esophagus Malignant melanoma of esophagus - - Malignant
A3 3 62 F Skin Malignant melanoma of right thumb T4N0M0 II Malignant
A4 4 62 F Skin Malignant melanoma of right thumb T4N0M0 II Malignant
A5 5 70 F Parotid gland Malignant melanoma of parotid gland T4N0M0 II Malignant
A6 6 70 F Parotid gland Malignant melanoma of parotid gland T4N0M0 II Malignant
B1 7 57 M Rectum Malignant melanoma of rectrum - - Malignant
B2 8 57 M Rectum Malignant melanoma of rectrum - - Malignant
B3 9 67 F Rectum Malignant melanoma of rectrum - - Malignant
B4 10 67 F Rectum Malignant melanoma of rectrum - - Malignant
B5 11 70 F Anus Malignant melanoma of anus (sparse) T4N0M0 II Malignant
B6 12 70 F Anus Malignant melanoma of anus (cataplasia tissue) T4N0M0 II Malignant
C1 13 66 M Rectum Malignant melanoma of rectrum - - Malignant
C2 14 66 M Rectum Malignant melanoma of rectrum - - Malignant
C3 15 54 F Rectum Malignant melanoma of rectrum - - Malignant
C4 16 54 F Rectum Malignant melanoma of rectrum - - Malignant
C5 17 82 F Rectum Malignant melanoma of rectrum - - Malignant
C6 18 82 F Rectum Malignant melanoma of rectrum - - Malignant
D1 19 52 F Rectum Malignant melanoma of rectrum - - Malignant
D2 20 52 F Rectum Malignant melanoma of rectrum - - Malignant
D3 21 49 F Skin Cancer adjacent normal chest skin tissue - - NAT
D4 22 49 F Skin Cancer adjacent normal chest skin tissue - - NAT
D5 23 50 F Skin Cancer adjacent normal skin tissue - - NAT
D6 24 50 F Skin Cancer adjacent normal skin tissue - - NAT
- 42 M Adrenal gland Pheochromocytoma (tissue marker) - - - Malignant
Notes: “*” means invalid core; “-” means no classification or negative in IHC markers.

AJCC-TNM classification for mucosal melanoma of the head and neck

T3 Mucosal disease
Primary Tumour
T3Mucosal disease
T4a Moderately advanced disease. Tumour involving deep soft tissue, cartilage, one, or overlying skin.
T4bVery advanced disease. Tumour involving brain, dura, skull base, lower cranial nerves (IX, X, XI, XII), masticator space, carotid artery, prevertebral space or mediastinal structures
Regional lymph nodes
NXRegional lymph nodes cannot be assessed
N0No regional lymph node metastases
N1Regional lymph node metastases present

Clinical stage
Stage IIIT3N0M0
Stage IVAT4aN0M0
T3-T4aN1M0
Stage IVBT4bAny NM0
Stage IVCAny TAny NM1

Vulvovaginal mucosal melanoma
Vulval melanomas are staged using the same AJCC-TNM classification as the table above. There is no staging system for vaginal melanoma, so a simplified clinical staging system can be used to categorise these melanomas.
Vaginal melanoma
Stage IClinically localized disease
Stage IIRegional nodal involvement
Stage IIIDistant metastatic involvement

Anorectal mucosal melanoma
Anorectal mucosal melanoma is staged using the same simplified staging system as vaginal melanoma.
Anorectal mucosal melanoma
Stage IClinically localized disease
Stage IIRegional nodal involvement
Stage IIIDistant metastatic involvement
Melanoma of the skins
Primary tumor (T)
* TX: Primary tumor cannot be assessed (e.g., shave biopsy or regressed melanoma)
* T0: No evidence of primary tumor
* Tis: Melanoma in situ
* T1: Tumor 1.0 mm or less in thickness with or without ulceration
  * T1a: Tumor 1.0 mm or less in thickness and Clarks level II or III, no ulceration
  * T1b: Tumor 1.0 mm or less in thickness and Clarks level IV or V or with ulceration
* T2: Tumor more than 1.0 mm but not more than 2.0 mm in thickness with or without ulceration
  * T2a: Tumor more than 1.0 mm but not more than 2.0 mm in thickness, no ulceration
  * T2b: Tumor more than 1.0 mm but not more than 2.0 mm in thickness, with ulceration
* T3: Tumor more than 2.0 mm but not more than 4 mm in thickness with or without ulceration
  * T3a: Tumor more than 2.0 mm but not more than 4 mm in thickness, no ulceration
  * T3b: Tumor more than 2.0 mm but not more than 4 mm in thickness, with ulceration
* T4: Tumor more than 4.0 mm in thickness with or without ulceration
  * T4a: Tumor more than 4.0 mm in thickness, no ulceration
  * T4b: Tumor more than 4.0 mm in thickness, with ulceration


Regional lymph nodes (N)

* NX: Regional lymph nodes cannot be assessed
* N0: No regional lymph node metastasis
* N1: Metastasis to 1 lymph node
  * N1a: Clinically occult (microscopic) metastasis
  * N1b: Clinically apparent (macroscopic) metastasis
* N2: Metastasis to 2 or 3 regional nodes or intralymphatic regional metastasis without nodal metastases
  * N2a: Clinically occult (microscopic) metastasis
  * N2b: Clinically apparent (macroscopic) metastasis
  * N2c: Satellite or in transit metastasis without nodal metastasis
* N3: Metastasis in 4 or more regional nodes, or matted lymph nodes, or in transit metastasis or satellite(s) with metastatic regional node(s)
Note: Micrometastases are diagnosed after elective or sentinel lymphadenectomy; macrometastases are defined as clinically detectable lymph nodes metastases confirmed by therapeutic lymphadenectomy, or when any lymph node metastasis exhibits gross extracapsular extension.
Distant Metastasis (M)
* MX: Distant metastasis cannot be assessed
* M0: No distant metastasis
* M1: Distant metastasis
  * M1a: Metastasis to skin, subcutaneous tissues, or distant lymph nodes
  * M1b: Metastasis to lung
  * M1c: Metastasis to all other visceral sites or distant metastasis at any site associated with an elevated serum lactic dehydrogenase (LDH)

Stage Groupings
Stage 0
  Tis, N0, M0
Stage IA
   T1a, N0, M0
Stage IB
   T1b, N0, M0
   T2a, N0, M0
Stage IIA
  T2b, N0, M0
  T3a, N0, M0
Stage IIB
  T3b, N0, M0
  T4a, N0, M0
Stage IIC
  T4b, N0, M0
Stage III
  Any T, N1, M0
   Any T, N2, M0
  Any T, N3, M0
Stage IV
  Any T, any N, M1